The No-React® process
Clinical studies show that owing to the efficacy of the No-React® process , there is no degradation or calcification of the valves after 18 years – in either young or old patients. Since there is no evidence of any deterioration of the valves and they also support the growth of endothelial cells the life expectancy is extrapolated to be for the life of the patient. BioIntegral Surgical will provide a warranty on the valves for the life of the patient such that if there were to be any valve related problems the valve would be replaced free of charge.
All BioIntegral Surgical devices are treated with the No-React® process which is a proprietary heparin rinsing technique for completely sealing the glutaraldehyde within the tissue (glutaraldehyde is used in all tissue devices to cross-link the tissue to form a polymer) . However it is the leaching of glutaraldehyde radicals and subsequent reaction with other chemical elements in the blood that is the cause of calcification, adhesions and degeneration in other tissue devices.Conventional Glutaraldehyde cross-linking leaves toxic free radicals (H-C=O) which react with foreign bodies to cause problems including calcification, adhesions and inflammatory response
With the No-React® process the glutaraldehyde is 100% sealed within the tissue and no leaching occurs.
The No-React® process is so effective that it has been clinically proven that a monolayer of endothelial cells forms on the No-React® tissue surface which then makes the valve 100% biocompatible. In study after study it has been shown that the devices do not calcify.
No-React Treated Tissue
No Glutaraldehyde Released - No Toxic Radicals
Conventional Glutaraldehyde Treated Tissue
Toxic Free Radicals leach out over time
Conventional Glutaraldehyde cross-linking leaves toxic free radicals (H-C=O) which react with foreign bodies to cause problems including calcification, adhesions and inflammatory response
No-React® Treatment seals in the glutaraldehyde radicals and so renders the tissue completely passive and biocompatible